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THE tooth fairy may soon have a new line of business. U.S.
doctors say they have managed to grow living pig teeth in
rats, a feat of biotechnology that experts said could spark a
dental revolution.
Researchers at Boston’s Forsyth Institute said Friday
their successful experiment suggests the existence of dental
stem cells, which could one day allow a person to replace a
lost tooth with an identical one grown from his or her own
cells.
“The ability to identify, isolate and propagate dental
stem cells to use in biological replacement tooth therapy has
the potential to revolutionize dentistry,” said Dominick
DePaola, president and CEO of the institute that focuses on
oral and facial science.
The experiment involved taking cells from immature teeth
of 6-month-old pigs, treating them with enzymes and then
placing the cell clusters on biodegradable “scaffolds” — tiny
bits of polymer designed to act like a mould for the forming
tissue.
The researchers implanted the scaffolds into the abdomens
of rats and within 30 weeks small recognizable tooth crowns —
containing enamel and dentin, a bone-like material found under
the enamel — had formed.
The researchers said they hope that within five years
they will have developed techniques to grow teeth of a
specific size and shape, and that within 10 years it will be
possible to regenerate human teeth.
Louis Terracio, associate dean of research at New York
University’s College of Dentistry, said the research signals
that the days of synthetic dental implants — dentures, bridges
and crowns — are numbered.
“Right now they do wonderful things with implants,”
Terracio said after reading the Forsyth research. “Implants
work pretty well but it’s not a natural tooth.”
(SD-Agencies)
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